When top-tier defenses are overwhelmed by much cheaper drones and decoys, missiles slower than hypersonic can find their targets, in spite of very heavy air defenses.
Iran demonstrated this April 13 against Israel from over 1k miles away, with amply-warned US, Jordanian, and Israeli interceptors all at furious work on them. Yet Iran managed to hit 2 Israeli airbases and a radar facility.
Such an attack may happen from Red Sea shores upon a US carrier with much less warning and ready response.